A med Question for Dan or BArry...

Discussion in 'More Serious Topics' started by Dwaine Scum, Dec 28, 2004.

  1. Dwaine Scum

    Dwaine Scum New Member

    Messages:
    11,130
    I recentyly started having Migraines (oct 30th to be percise) anyway, I just found a new doctor, and I am getting back on track, they have kinda narrowded it down to Tension headaches turnignto migraines. the new doctor has given me samoles of a med called Relpax. Have you heard of this med? anything I should know about it? The Doctor told me "when you are having a migrane, take one tablet, if the migraine is not gone in an hour, take the other pill (there are two pills per pack)
     
  2. ucicare

    ucicare Active Member

    Messages:
    5,606

    I suspect that the tension headaches start as a neck ache from sitting in front of the computer looking at porn all day.

    I really don't know much about meds other than those used in treating mental disorders. I defer to Dan the Medical Man on the med question.

    Barry
     
  3. Dwaine Scum

    Dwaine Scum New Member

    Messages:
    11,130
    Close, slumped over a torch melting glass all day
     
  4. ucicare

    ucicare Active Member

    Messages:
    5,606

    Seriously Dwaine, could toxic fumes from the torch or glass or any other additives be causing it? I used to do some welding, but had to quit because the fumes made me so sick. The invisible gases from the torch or glass could easily be a problem.

    Do you get headaches on the days you don't do glass?

    Barry
     
  5. DangerousDan

    DangerousDan New Member

    Messages:
    1,630
    I don't know much about migraines or the meds yet. You should get a pretty detailed description of the drug and contraindications and so forth if the dr. prescribes it when you pick up the medication at the pharmacy. Apparently it is a new drug that came out in 2003. Here is what a brief search on the internet pulled up:

    RELPAX is a prescription medicine and is intended to relieve migraine attacks in adults. RELPAX is not intended to prevent attacks from happening. RELPAX is not for everyone. You should not take RELPAX if you have risk factors for heart disease or stroke, including heart disease in your family, high cholesterol, high blood pressure, diabetes, or obesity. Also, if you are past menopause or if you smoke.

    RELPAX is generally well tolerated. As with any medicine, people taking RELPAX may have side effects. The side effects are usually mild and do not last long. Most common side effects are dizziness, nausea, weakness, feeling sleepy, pain or a pressure sensation in the chest or throat. Medicines in this class have been associated with very rare reports of serious heart-related problems.

    Before taking RELPAX, be sure to tell your doctor about any medicines you are taking or plan to take. As with other medicines in this class, RELPAX should not be taken within 24 hours of another triptan or ergotamine. RELPAX should not be taken within 72 hours of the following medicines: Biaxin® (clarithromycin), Nizoral® (ketoconazole), Norvir® (ritonavir), Serzone® (nefazodone), Sporanox® (itraconazole), TAO® (troleandomycin), and Viracept® (nelfinavir).

    Drug Name: Replax (Eletriptan)
    FDA Approval Date: December 26, 2002
    Indications (for treatment of): Relpax is a prescription medicine used to treat migraine headaches in adults. Relpax is not for other types of headaches. Treatment with Relpax reduces swelling of blood vessels surrounding the brain. This swelling is associated with the headache pain of a migraine attack. Relpax blocks the release of substances from nerve endings that cause more pain and other symptoms like nausea and sensitivity to light and sound. Relpax is a new triptan available by prescription for the treatment of acute migraine. Currently five triptans are available by prescription and more are under development. Migraine therapy is largely based on the use of medications, although some patients may respond to other measures, such as stress reduction, exercise, discontinuation of an oral contraceptive, or avoidance of certain foods or beverages, most notably red wine.


    emedicine:
    Drug Category: 5- HT1 Serotonin receptor agonist -- The stimulation of 5-HT1 receptors produce a direct vasoconstrictive effect.
    Drug Name Sumatriptan (Imitrex), frovatriptan (Frova), eletriptan (Relpax) -- naratriptan (Amerge, Naramig)--Selective agonist for serotonin 5-HT1 receptors in cranial arteries. Suppresses inflammation associated with migraine headaches.
    Frovatriptan possesses long half-life (ie, 26-30 h), decreasing recurrence of migraine within 24 h after treatment.
    Eletriptan half-life is 18 h.
    Naratriptan has a duration of action of up to 24 h, with low headache recurrence rate.
    Adult Dose Sumatriptan: 25 mg PO; if satisfactory response not observed in 2 h, additional dose of up to 100 mg may be administered; additional doses at intervals of 2 h prn; not to exceed 300 mg/d
    6 mg SC; if satisfactory response not observed in 1 h, an additional 6 mg SC may be administered; not to exceed 2 injections/d
    Intranasal: Single dose of 5, 10, or 20 mg may be administered in 1 nostril; give 10-mg dose by administering single 5-mg dose in each nostril; if satisfactory response not observed in 2 h, additional dose may be administered; not to exceed 40 mg/d
    Frovatriptan: 2.5 mg PO once at onset of migraine attack
    Eletriptan: 20-40 mg/dose PO at onset of migraine; if initial dose ineffective, may repeat dose once after 2 h; not to exceed 80 mg/d
    Naratriptan: 1-2.5 mg PO q4h prn for headache; not to exceed 5 mg/d
    Pediatric Dose Not established
    Contraindications Documented hypersensitivity; ischemic heart disease; uncontrolled hypertension; coadministration or within 2 wk of MAOIs; severe hepatic impairment (eletriptan); age >65 y; administration within 72 h of potent CYP3A4 inhibitors (eletriptan)
    Interactions Toxicity may increase when used within 24 h of ergotamines or other 5-HT agonists; coadministration with SSRIs may cause weakness, hyperreflexia, or incoordination; CYP3A4 inhibitors (eg, ketoconazole, itraconazole, ritonavir, erythromycin) may increase plasma concentration and subsequent toxicity
    Pregnancy C - Safety for use during pregnancy has not been established.
    Precautions Hypertensive crisis, coronary artery vasospasm, cardiac arrest, peripheral ischemia, and bloody diarrhea may occur rarely
    Patients with known or suspected coronary artery disease may have increased risk of myocardial ischemia, infarction, or other cardiac or cerebrovascular events (5-HT1 agonists may cause coronary vasospasm
    Drug Name Zolmitriptan (Zomig, Zomig-ZMT), almotriptan (Axert) -- rizatriptan (Maxalt, Maxalt-MLT)--Selective agonist for serotonin 5-HT1 receptors in cranial arteries. Suppresses inflammation associated with migraine headaches.
    Adult Dose Zolmitriptan: 2.5 mg or 5 mg PO; repeat dose after 2 h prn; not to exceed 10 mg/d
    Almotriptan: 6.25-12.5 mg PO at onset of migraine; may repeat once, not to exceed 25 mg/d
    Rizatriptan: 5-10 mg PO q2h prn for headache; not to exceed 30 mg/d
    Pediatric Dose Not established
    Contraindications Documented hypersensitivity; ischemic heart disease; uncontrolled hypertension; another serotonin agonist or ergotamine within last 24 h; MAOI within last 2 wk
    Interactions Toxicity may increase when used within 24 h of ergotamines or other 5-HT agonists; coadministration with SSRIs may cause weakness, hyperreflexia, or incoordination; CYP3A4 inhibitors (eg, ketoconazole, itraconazole, ritonavir, erythromycin) may increase plasma concentration and subsequent toxicity
    Pregnancy X - Contraindicated in pregnancy
    Precautions Hypertensive crisis, coronary artery vasospasm, cardiac arrest, peripheral ischemia, bloody diarrhea, and death may occur
    Decrease dose of almotriptan and do not exceed 12.5 mg/d in renal or hepatic impairment
     

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